#Spindle cell sarcoma full

However a CT scan of his chest did not show any mediastinal mass or lymphadenopathy. There was also an increase in FDG avidity with SUV 6 in the right paratracheal region of concern for a second primary malignancy.

#Spindle cell sarcoma full

The patient underwent a positron emission tomography scan of the full body which showed FDG avidity in the anterior larynx with SUV of 3.6 consistent with his vocal cord mass but no increased FDG avidity within the neck. Epithelial membrane antigens (EMA) was positive. Immunohistochemistry: cytokeratin AE1/AE3, strongly positive diffuse nuclear staining of neoplastic cells, Ck 5/6, strongly positive nuclear cytoplasmic staining of neoplastic cells, vimentin, strongly positive. There was no adenopathy noted however (Figure 1). The parotid gland and submandibular salivary glands were normal however the CT showed that the thyroid gland was enlarged. The patient did not have any supraclavicular lymph nodes bilaterally.Ī CT scan of his neck with contrast revealed a 7 mm polypoid mass involving the anterior commissure of the vocal cords however the nasopharynx, pharynx, peripharyngeal spaces and epiglottis appeared unremarkable. Physical examination of the patient showed a very small palpable lymphadenopathy in the anterior cervical region more pronounced on the right compared to the left. In the clinic, the patient had difficulty in speaking and hoarseness of in voice. The patient history was significant for 60 packs years of smoking. The patient also described a 20-pound weight loss over the last several months due to his dysphagia and odynophagia. Case ReportĪ 67-year-old Caucasian male presented to the internal medicine clinic with 2-month history of progressive hoarseness that has been affecting his ability to speak and dysphagia. The following is a case report of one such patient who presented to our institution with spindle cell (sarcomatoid) carcinoma of the larynx. Since a majority of these tumors are polypoid or pedunculated and tend to cause obstructive symptoms, these tumors are often detected at an early stage, removed by polypectomy during diagnosis, and tend to have a very good prognosis. Spindle cell carcinoma is considered to be a biphasic tumor that is composed of a squamous cell carcinoma (in situ or invasive) and spindle cell carcinoma with sarcomatous appearance.

Squamous cell carcinoma is the most malignant carcinoma of the larynx, and spindle cell (sarcomatoid) tumor is considered a highly malignant variant of squamous cell carcinoma. Spindle cell (sarcomatoid) carcinoma of the larynx is a rare tumor and comprises 2% to 3% of all laryngeal cancers.

His symptoms gradually improved, and he regained good control of his voice. The patient underwent direct laryngoscopy with excision of the malignant mass and received radiation therapy. We present a case of spindle cell carcinoma in a 67-year-old Caucasian male who presented with progressive hoarseness of his voice, dysphagia, odynophagia and a 20-pound weight loss. Most spindle cell tumors are polypoid and pedunculated they are often detected at an early stage, removed by polypectomy during diagnosis, and tend to have a very good prognosis. It is considered to be a biphasic tumor that is composed of a squamous cell carcinoma (in situ or invasive) and spindle cell carcinoma with sarcomatous appearance. Spindle cell carcinoma (SpCC) or sarcomatoid carcinoma is a highly malignant variant of squamous cell carcinoma which comprises 2% to 3% of all laryngeal cancers.